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Nearly every function of your body depends on enzymes to make everything happen. Enzyme become active when specific minerals such as zinc, magnesium, calcium, copper and others link with the activation site on the enzyme.
Each mineral has a unique shape and properties. The activation sites are like a key lock and can only be activated by a specific mineral. Heavy metal block the activation sites and prevent the enzyme from becoming active.
For example, if it take 100 enzymes to complete a function and 10 of them are blocked by heavy metals the reaction will not be as complete. The more enzymes that are block the greater the problem.